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Monday, May 18, 2020 | History

1 edition of Effect of glucose on the amino acid response to protein ingestion in diabetic and normal man found in the catalog.

Effect of glucose on the amino acid response to protein ingestion in diabetic and normal man

by James Lawrence Rosenzweig

  • 71 Want to read
  • 39 Currently reading

Published by s.n.] in [New Haven .
Written in English

    Subjects:
  • Glucose,
  • Proteins,
  • Metabolism,
  • Diabetes

  • Edition Notes

    Other titlesEffect of glucose on protein metabolism.
    The Physical Object
    Pagination59 leaves ;
    Number of Pages59
    ID Numbers
    Open LibraryOL26388692M
    OCLC/WorldCa689613001

      In a previous study in which normal young males ingested 50 g protein in the form of casein, we reported that the ingested protein did increase the glucose appearance rate, but this was considerably less than expected from the amount of amino acids deaminated and the resulting amino Cited by: Abstract. To evaluate the effects of physiologic hyperglucagonemia on splanchnic glucose output, glucagon was infused in a dose of 3 ng/kg per min to healthy subjects in the basal state and after splanchnic glucose output had been inhibited by an infusion of glucose Cited by:

    Unlike glucose neither beta-hydroxybutyrate or octanoic acid had any demonstrable effects on protein degradion. The addition of amino acids at plasma concentrations both promoted protein synthesis.   Abstract. Background: Milk protein, in particular the whey fraction, has been shown to display insulinotrophic properties in healthy persons and persons with type 2 diabetes. In parallel to the hyperinsulinemia, a pronounced postprandial rise of certain amino acids and of glucose Cited by:

      Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks. Am J Clin Nutr ; – CASCited by: The subjects were studied in the basal postabsorptive state and following the infusion of alanine ( g/kg) or ingestion of a protein meal. In nonobese subjects dexamethasone treatment resulted in a 55% increment in basal glucagon levels and in a % increase in the maximal glucagon response to alanine infusion or protein ingestion.


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Effect of glucose on the amino acid response to protein ingestion in diabetic and normal man by James Lawrence Rosenzweig Download PDF EPUB FB2

Concentrations in plasma after protein ingestion. Normal subjects ingested a mixture of raw eggs and milk containing approximately 60 gm of protein, and the venous plasma amino acid concentrations were determined at hourly intervals for eight hours after the meal.

The pattern of amino acid rise Author: James Lawrence Rosenzweig. The effect of protein ingestion on the metabolic response to oral glucose innormal individuals. Krezowski PA, Nuttall FQ, Gannon MC, Bartosh NH.

Eight normal subjects were given 50 g protein, 50 g glucose, or 50 g protein + 50g by:   Subsequently AAN and glucagon increased to levels greater than or equal to those observed after protein ingestion alone.

In summary, protein is a much less potent secretagogue for insulin than is glucose in normal individuals, and the effect on insulin secretion is not synergistic.

Addition of glucose to a protein meal results in a delayed rise in AAN and glucagon Cited by: Rising plasma levels of certain amino acids after protein feeding can be considered to be physiologic stimuli for the secretion of insulin. It is speculated that the purpose of the insulinogenic response to protein ingestion is to aid in the utilization of absorbed amino acids and in their synthesis to by: When various amounts of protein were given 50 g glucose, the insulin area response was essentially first order.

Subsequently, subjects were given 50 g glucose or 50 g glucose with 50 g protein as two Cited by:   The majority of amino acids attenuate the glucose response to glucose when ingested with glucose. The amino acids had only a small additional effect on insulin secretion when ingested with by: Branched-chain amino acid response to protein ingestion significantly correlated with blood glucose response to oral glucose (r = ), and with insulin resistance during the glucose tolerance test, Cited by: Independent and Combined Effects of Amino Acids and Glucose after Resistance Exercise.

Med. Sci. Sports Exerc., Vol. 35, No. 3, pp. –, Purpose: This study was designed to assess the independent and combined effects of a dose of amino acids File Size: KB.

The insulinogenic effect appears to be mediated through a specific postprandial amino acid (AA) pattern appearing in plasma following whey ingestion, with the highest responses found for lysine (lys), threonine (thr) and the branched chained amino acids (BCAA) leucine (leu), isoleucine (iso) and valine (val).Cited by: The effect of individual dietary components on glucagon secretion is diverse.

Animal protein intake stimulates whereas glucose and fatty acids ingestion inhibits glucagon secretion. The intake of a standard meal that contains glucose, amino acids and fatty acids Cited by: 2.

Type II diabetic subjects were given 50 g protein, 50 g glucose, or 50 g glucose with 50 g protein as a single meal in random sequence.

The plasma glucose and insulin response was determined over the subsequent 5 h. The plasma glucose area above the baseline following a glucose meal was reduced 34% when protein was given with the glucose. When protein was given alone, the glucose Cited by: Protein: Metabolism and Effect on Blood Glucose Levels Article Literature Review (PDF Available) in The Diabetes Educator 23(6),November with 2, Reads.

amino acids had larger effects. The three branched chain amino acids together stimulated synthesis and reduced degra- dation, while the remaining plasma amino acids did not affect either process significantly. Thus leucine, isoleucine, and valine appear responsible for the effects of plasma amino acids on protein.

Effect of Protein Ingestion on the Glucose and Insulin Response to a Standardized Oral Glucose Load Article (PDF Available) in Diabetes Care 7(5) September with 1, Reads.

In the normal subjects, after protein ingestion, there was a large amino acid release from the splanchnic bed predominantly involving the branched chain amino acids. Valine, isoleucine, and leucine accounted together for more than half of total splanchnic amino acid by: The Insulin and Glucose Responses to Meals of Glucose Plus Various Proteins in Type II Diabetic Subjects Mary C.

Gannon, Frank 0. Nuttall, Brian J. Neil, and Sydney A. Westphal We previously have shown that ingested beef protein is just as potent as glucose in stimulating a rise in insulin concentration in type 11 diabetic Cited by: Oxidation of branched chain amino acids by isolated hearts and diaphragms of the rat.

The effect of fatty acids, glucose, and pyruvate respiration. J Biol Chem. Dec 25; (24)– FRAME EG. The levels of individual free amino acids in the plasma of normal man at various intervals after a high-protein.

Plasma concentrations of amino acids were measured and protein turnover was estimated using l-(C)lysine and l-(3,3,H3)leucine as tracers. Glucose kinetics were measured using d-(6,H2. Of the 20 amino acids found in proteins, all but leucine could, at least in part, be converted into glucose and thus contribute to the circulating glucose pool.

However, data from many laboratories, including our own, confirmed that ingested protein per se does not increase the circulating glucose Cited by: 5.

the ingestion of a protein-rich meal in normal man. Moreover, the effect of diabetes mellitus with its at-tendant alterations in insulin and glucagon secretion (14) on the metabolic response to a protein meal has not been established.

It may be speculated that an altered hormonal response to protein ingestion in dia-betes may influence regional exchange of glucose and amino Size: 2MB. The fate of amino acids deaminated following protein ingestion is uncertain.

Presumably, the majority of the carbon skeletons of the amino acids are converted into glucose in the liver.Effects of Fat and Protein on Blood Glucose Levels. The effects of slowly digested fats and proteins on blood glucose are minimal in people without diabetes who produce sufficient insulin.

In people with diabetes, however, the effects of fat and protein. Protein: Metabolism and Effect on Blood Glucose Levels Show all authors Billington C., Krezowski P.

Effect of protein ingestion on the glucose and insulin response to a standardized oral Sinclair-Smith BC Liljenquist JE Transient stimulatory effect of sustained hyperglucagonemia on splanchnic glucose production in normal and diabetic by: